埃萬妥單抗破局EGFR-TKI耐藥困境，在EGFR突變NSCLC治療領(lǐng)域展現(xiàn)廣闊前景。

*以下內(nèi)容僅供醫(yī)療衛(wèi)生專業(yè)人士瀏覽。

參考文獻：

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[2] Liao X, He T, Wan X, et al. Clinical management in NSCLC patients with EGFR mutation after osimertinib progression with unknown resistance mechanisms[J]. The Clinical Respiratory Journal, 2024, 18(10): e70025.

[3] Alissa J. C, Lecia V. S & Jessica J. L.Third-generation EGFR and ALK inhibitors: mechanisms of resistance and management.Nature Reviews Clinical Oncology, 2022.

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[8] ShihJ, Wang J, Wang Y, et al. Amivantamab plus chemotherapy vs chemotherapy among Asian patients with EGFR-mutant advanced NSCLC after progression on osimertinib: A MARIPOSA-2 subgroup analysis. 2023 ESMO Asia. LBA11.

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[10] Zhao W, Zhou W, Rong L, et al. Epidermal growth factor receptor mutations and brain metastases in non-small cell lung cancer. Front Oncol. 2022. 12: 912505.

[11] Califano R, Passaro A, Tan JL, et al. Amivantamab plus chemotherapy vs chemotherapy in EGFR-mutant advanced NSCLC after disease progression on osimertinib: Outcomes by osimertinib resistance mechanisms in MARIPOSA-2. 2025 ASCO. Abstract 8639.

審批編碼：CP-556189

批準分發(fā)日期：12/10/2025

有效期：12/10/2026

*“醫(yī)學(xué)界”力求所發(fā)表內(nèi)容專業(yè)、可靠，但不對內(nèi)容的準確性做出承諾；請相關(guān)各方在采用或以此作為決策依據(jù)時另行核查。